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教师内容页
校蕾  
研究领域(方向)

1.心血管病:动脉粥样硬化及血管再狭窄分子病理机制研究;

2.糖尿病防治:糖尿病血管病变的分子机制研究;

3.受体与基因表达的调控:血管分子机械——生物信号转导研究。

个人及工作简历

教育经历:

(1) 2007.09–2012.07,  北京师范大学,  生理学,  博士

(2) 2003.09–2007.07,  西北大学,  生物技术,  学士

科研与学术工作经历:

(1) 2018.01-至今, 亚博全站手机网页登录医学部, 心血管研究中心, 副教授

(2) 2015.04-2016.06, 美国佐治亚州立大学, 分子转化医学研究中心, 博士后

(3) 2014.04-2015.04, 美国俄克拉荷马大学, 分子医学中心, 博士后

(4) 2012.07-2017.12, 亚博全站手机网页登录医学部, 心血管研究中心, 讲师

科研项目

1.国家自然科学基金面上项目,四氢生物蝶呤合成酶GTPCH1和DHFR的泛素化降解与尼古丁诱导内皮功能紊乱的机制, 在研,主持

2.医学部国家级后备人选支持计划:医学攀登人才计划, 亚博全站手机网页登录医学部, 在研,主持

3.国家自然科学基金青年科学基金项目,81300242,RORα通过调控炎症小体拮抗AngII诱导的内皮损伤,已结题,主持

学术及科研成果、专利、论文

5年以第一/通讯作者发表论文情况:

1.      Zhang Z, Xie X, Yao Q, Liu J, Tian Y, Yang C, Xiao L*, Wang N*. PPARδ agonist prevents endothelial dysfunction via induction of dihydrofolate reductase gene and activation of tetrahydrobiopterin salvage pathway. Br J Pharmacol. 2019; 176(16): 2945-2961.

2.      Tian Y, Yang C, Yao Q, Qian L, Liu J, Xie X, Ma W, Nie X, Lai B, Xiao L*, Wang N*. Procyanidin B2 activates PPARγ to induce M2 polarization in mouse macrophages. Front Immunol. 2019;10:1895.

3.      Xie X, Yang C, Cui Q, Ma W, Liu J, Yao Q, Zhang Z, Xiao L*, Wang N*. Stachydrine Mediates Rapid Vascular Relaxation: Activation of Endothelial Nitric Oxide Synthase Involving AMP-Activated Protein Kinase and Akt Phosphorylation in Vascular Endothelial Cells. J Agric Food Chem. 2019;67(35):9805-9811.

4.      Zhang M, Zhang Z, Xie X, Yao Q, Liu J, Lai B, Xiao L*, Wang N*. Xenobiotic pregnane X receptor promotes neointimal formation in balloon-injured rat carotid arteries. J Cell Physiol. 2019;234(4):4342-4351.

5.      Li C#, Xiao L#, Jia J, Li F, Wang X, Duan Q, Jing H, Yang P, Chen C, Wang Q, Liu J, Shao Y, Wang N*, Zheng Y*. Cornulin Is Induced in Psoriasis Lesions and Promotes Keratinocyte Proliferation via Phosphoinositide 3-Kinase/Akt Pathways. J Invest Dermatol. 2019;139(1):71-80.

6.      Xie X, Zhang Z, Wang X, Luo Z, Lai B, Xiao L*, Wang N*. Stachydrine protects eNOS uncoupling and ameliorates endothelial dysfunction induced by homocysteine. Mol Med. 2018;24(1):10.

7.      李帆,张子绘,谢新雅,校蕾*汪南平*。增塑剂邻苯二甲酸二丁酯致血管内皮功能损伤及其机制,中国科学 生命科学  2018;48(5):535-543.

8.      Wang S, Xie X, Lei T, Zhang K, Lai B, Zhang Z, Guan Y, Mao G, Xiao L*, Wang N*. Statins Attenuate Activation of the NLRP3 Inflammasome by Oxidized LDL or TNFα in Vascular Endothelial Cells through a PXR-Dependent Mechanism. Mol Pharmacol. 2017;92(3):256-264.

9.      Zhang Z#, Jiang M#, Xie X, Yang H, Wang X, Xiao L*, Wang N*. Oleanolic acid ameliorates high glucose-induced endothelial dysfunction via PPARδ activation. Sci Rep. 2017;7:40237.

10.   张子绘#,汤伟琦#,李帆,校蕾*汪南平。异源物代谢核受体 PXR 和 CAR 在血管疾病中的作用。生理科学进展 2017;48:(5) pp.341-346

11.   Xiao L#, Zhang Z#, Luo X, Yang H, Li F, Wang N*. Retinoid acid receptor-related orphan receptor alpha (RORα) regulates macrophage M2 polarization via activation of AMPKα. Mol Immunol. 2016; 80: 17–23.

12.   Ni J, Zhang Z, Luo X, Xiao L*, Wang N*. Plasticizer DBP Activates NLRP3 Inflammasome through the P2X7 Receptor in HepG2 and L02 Cells. J Biochem Mol Toxicol. 2016; 30(4):178-85.

13.   Xiao L#, Wang J#, Li J, Chen X, Xu P, Sun S, He D, Cong Y, Zhai Y*. RORα inhibits adipocyte-conditioned medium - induced colorectal cancer cell proliferation and migration and chick embryo chorioallantoic membrane angiopoiesis. Am J Physiol Cell Physiol. 2015; 308(5):C385-96.

著作列表:

1.  Xiao L, Wang J, Jiang M, Xie W, Zhai Y*. The emerging role of Constitutive Androstane Receptor and its cross talk with Liver X Receptors and Peroxisome Proliferator-Activated Receptors in lipid metabolism. Vitamins and Hormones, edited by Gerald Litwack, Academic Press, 2013.

2.  汪南平、校蕾,核受体与血管病变,血管生物学,北京大学医学出版社,2014.

联系方式
电子邮箱:xiaolei0122@xjtu.edu.cn
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更新日期:2020-02-10